Description

5-Chlorosulfonyl-2-Methoxybenzoic Acid-D3 is a high-purity, deuterium-labeled derivative of a key benzoic acid sulfonyl chloride intermediate. This compound is specifically valued for its role as a stable isotope-labeled internal standard in quantitative analytical methods, ensuring unparalleled accuracy and reliability in trace-level detection. It is primarily utilized by research scientists and process chemists in the pharmaceutical and agrochemical industries for advanced method development, metabolic studies, and quality control of active pharmaceutical ingredients (APIs).

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference standard in Liquid Chromatography-Tandem Mass Spectrometry for the precise quantification of parent compounds or metabolites in complex biological matrices.
• Pharmaceutical Research & Development: Used in the synthesis and analytical profiling of deuterated drug candidates, supporting pharmacokinetic (PK) and pharmacodynamic (PD) studies.
• Metabolite Identification & Tracing: Enables accurate tracking and identification of drug metabolites in in vitro and in vivo studies due to its isotopic label.
• Process Chemistry & Impurity Profiling: Acts as a reference marker to monitor reaction pathways, identify impurities, and ensure batch-to-batch consistency in API manufacturing.
• Agrochemical Analysis: Employed in the environmental and residue analysis of sulfonylurea-based herbicides and related compounds.
• Custom Synthesis Building Block: Provides a versatile, labeled synthon for the preparation of more complex deuterated molecules for specialized research applications.

Basic Information

Product Name	5-Chlorosulfonyl-2-Methoxybenzoic Acid-D3
CAS No.	123958-84-9
Molecular Formula	C8H2D3ClO5S
Molecular Weight	~263.66 g/mol
Synonyms	2-Methoxy-5-(chlorosulfonyl)benzoic-2,4,6-D3 acid; 5-(Chlorosulfonyl)-2-methoxybenzoic-2,4,6-D3 acid; Deuterated Mesalamine Impurity; Benzoic-2,4,6-D3 acid, 5-(chlorosulfonyl)-2-methoxy-; Mesalazine-d3 related compound; 5-Sulfonyl chloride-2-methoxybenzoic acid-d3; Deuterium Labeled 5-Chlorosulfonyl-2-Methoxybenzoic Acid
EINECS	Contact for details

Quality Control

Every batch of 5-Chlorosulfonyl-2-Methoxybenzoic Acid-D3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC assay, NMR for deuterium incorporation, and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. Our quality commitment ensures the material meets the stringent requirements for analytical and synthetic applications in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.