Description

(6Ar-Trans)-1-[(tert-Butyl)Dimethylsilyloxy]-6A,7,8 is a high-purity, advanced pharmaceutical intermediate featuring a protected hydroxyl group via a tert-butyldimethylsilyl (TBDMS) ether. This compound is critical for synthetic chemists requiring precise stereochemical control and moisture-sensitive functional group protection in complex multi-step syntheses. It is primarily utilized in the research and development of novel active pharmaceutical ingredients (APIs), particularly within the pharmaceutical and fine chemical sectors.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex steroid derivatives and other bioactive molecules.
• Organic Synthesis: Used as a protected synthon in multi-step organic reactions where temporary hydroxyl group masking is required.
• Process Chemistry: Employed in the development and scale-up of manufacturing routes for target drug candidates.
• Academic & Industrial R&D: Serves as a valuable reagent for methodological studies in synthetic organic chemistry and medicinal chemistry programs.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value chemical entities.

Basic Information

Product Name	(6Ar-Trans)-1-[(tert-Butyl)Dimethylsilyloxy]-6A,7,8
CAS No.	123718-51-4
Molecular Formula	C₁₆H₃₀O₂Si
Molecular Weight	282.50 g/mol
Synonyms	1-[(1,1-Dimethylethyl)dimethylsilyl]oxy-(6ar-trans)-6a,7,8,9,10,10a-hexahydro-6H-dibenzo[b,d]pyran-6-ol; TBDMS Ether of (6ar-trans)-6a,7,8,9,10,10a-hexahydro-6H-dibenzo[b,d]pyran-6-ol; (6ar-trans)-6a,7,8,9,10,10a-Hexahydro-6H-dibenzo[b,d]pyran-6-ol, 1-[(1,1-dimethylethyl)dimethylsilyl] ether; (6ar-trans)-1-(tert-Butyldimethylsilyloxy)-6a,7,8,9,10,10a-hexahydro-6H-dibenzo[b,d]pyran-6-ol
EINECS	Contact for details

Quality Control

Our (6Ar-Trans)-1-[(tert-Butyl)Dimethylsilyloxy]-6A,7,8 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.