Description

3-Chloroisoquinoline-4-Carboxylic Acid is a high-purity, versatile heterocyclic building block of significant interest in advanced organic synthesis. This compound serves as a critical precursor for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for its reactive chlorinated isoquinoline core.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly those targeting neurological disorders and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science: Employed in the synthesis of organic semiconductors, light-emitting materials, and other functional organic compounds.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis: A foundational block for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.

Basic Information

Product Name	3-Chloroisoquinoline-4-Carboxylic Acid
CAS No.	123695-38-5
Molecular Formula	C10H6ClNO2
Molecular Weight	207.61 g/mol
Synonyms	3-Chloro-4-isoquinolinecarboxylic Acid; 4-Carboxy-3-chloroisoquinoline; 3-Chloroisoquinoline-4-carboxylic acid; 3-Chloro-1,2-dihydro-4-isoquinolinecarboxylic Acid (tautomer); 3-Chloro-4-isoquinoline carboxylic acid; 3-Chloro-4-carboxyisoquinoline; Isoquinoline-4-carboxylic acid, 3-chloro-
EINECS	Contact for details

Quality Control

Our 3-Chloroisoquinoline-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, supporting compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.