Description

8-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline is a fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because the fluorine atom and the tetrahydroisoquinoline scaffold confer unique electronic and steric properties, enabling the development of novel molecules with enhanced biological activity and metabolic stability. It is primarily needed by pharmaceutical and agrochemical R&D teams for use as a key intermediate in the creation of active pharmaceutical ingredients (APIs), drug candidates, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing fluorinated drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the fluorine atom improves efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tag in the design of enzyme inhibitors and biochemical probes.
• Academic & Contract Research: Essential for methodological development in organic chemistry and medicinal chemistry programs.
• Custom Synthesis & Scale-Up: A starting material for contract manufacturing organizations (CMOs) producing bespoke fine chemicals for clients.

Basic Information

Product Name	8-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline
CAS No.	123594-01-4
Molecular Formula	C9H10FN
Molecular Weight	151.18 g/mol
Synonyms	8-Fluoro-1,2,3,4-tetrahydroisoquinoline; 8-Fluorotetrahydroisoquinoline; 1,2,3,4-Tetrahydro-8-fluoro-isoquinoline; 8-Fluoro-THIQ; 8-Fluoro-3,4-dihydro-1H-isoquinoline; 8-Fluoro-1,2,3,4-tetrahydroquinoline (incorrect but common); 8-Fluoro-THIQ base
EINECS	Contact for details

Quality Control

Our 8-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.