Description

5-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure makes it a critical intermediate for the development of novel pharmaceutical compounds and agrochemicals. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key scaffold in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets, receptor modulators, and enzyme inhibitors.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atom can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Material Science Precursor: Acts as a building block for advanced organic materials, such as liquid crystals or organic semiconductors.
• Chemical Biology Probe: Utilized in the design and synthesis of molecular probes for studying biological systems and disease mechanisms.

Basic Information

Product Name	5-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline
CAS No.	123594-00-3
Molecular Formula	C9H10FN
Molecular Weight	151.18 g/mol
Synonyms	5-Fluoro-1,2,3,4-tetrahydroisoquinoline; 5-Fluoro-THIQ; 5-Fluoro-3,4-dihydro-1H-isoquinoline; 5-Fluoro-1,2,3,4-tetrahydro-isoquinoline; 5-F-THIQ; 5-Fluoro-1,2,3,4-tetrahydroquinoline (incorrect but common); 5-Fluoro-3,4-dihydroisoquinoline
EINECS	Contact for details

Quality Control

Our 5-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can support development projects with custom purity grades and analytical method development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.