Description

3-Amino-5-Chlorothiophene is a versatile heterocyclic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both an amino and a chloro substituent on the thiophene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of various drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science: Serves as a monomer or building block for conductive polymers, organic semiconductors, and other functional organic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate in the production of specialized dyes and organic pigments.
• Research & Development: Essential compound for medicinal chemistry and process chemistry research in both academic and industrial settings.
• Ligand and Catalyst Preparation: Used to synthesize novel ligands for metal complexes and catalysts used in cross-coupling reactions.

Basic Information

Product Name	3-Amino-5-Chlorothiophene
CAS No.	123403-75-8
Molecular Formula	C4H4ClNS
Molecular Weight	133.60 g/mol
Synonyms	5-Chloro-3-thiophenamine; 5-Chlorothiophen-3-amine; 3-Amino-5-chlorothiophene; 5-Chloro-3-aminothiophene; 3-Thiophenamine, 5-chloro-; 5-Chloro-1,3-thiazol-4-amine (tautomer consideration); 3-Amino-5-chloro-thiophene
EINECS	Contact for details

Quality Control

Our 3-Amino-5-Chlorothiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its light-sensitive nature and propensity for oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.