Description

2-(Tritylamino)-α-(Methoxyimino)-4-Thiazoleacetic Acid Hydrochloride is a specialized organic salt with a complex molecular structure, serving as a key intermediate in advanced pharmaceutical synthesis. Its primary value lies in enabling the production of high-purity active pharmaceutical ingredients (APIs), particularly within the cephalosporin class of antibiotics. This compound is essential for research institutions and manufacturers in the pharmaceutical and fine chemical industries who require precise building blocks for complex molecule construction. The material is supplied with rigorous quality control to ensure batch-to-batch consistency for critical synthetic pathways.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced cephalosporin antibiotics.
• API Synthesis: Used in the research and development of novel active pharmaceutical ingredients requiring a protected amino-thiazole acetic acid moiety.
• Fine Chemical Production: Serves as a precursor in multi-step organic synthesis for high-value specialty chemicals.
• Biochemical Research: Employed in academic and industrial laboratories for studying structure-activity relationships and developing new therapeutic agents.
• Process Chemistry: Utilized in scale-up and optimization of manufacturing routes for antibiotic drugs.

Basic Information

Product Name	2-(Tritylamino)-α-(Methoxyimino)-4-Thiazoleacetic Acid Hydrochloride
CAS No.	123333-74-4
Molecular Formula	C26H24N4O3S • HCl
Molecular Weight	509.02 g/mol (Free base: 472.56 g/mol)
Synonyms	2-[(Triphenylmethyl)amino]-α-(methoxyimino)-4-thiazoleacetic acid hydrochloride; (Z)-2-(2-Amino-4-thiazolyl)-2-[(triphenylmethoxy)imino]acetic acid methyl ester hydrochloride (related ester); 2-(Tritylamino)-α-(methoxyimino)-4-thiazoleacetic acid HCl; ATMA Hydrochloride; Cephalosporin intermediate 7-ACA side chain precursor; 7-ACA Synthon; Trityl-protected aminothiazole oxime acetic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(Tritylamino)-α-(Methoxyimino)-4-Thiazoleacetic Acid Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, ensuring it meets the stringent requirements for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance with cGMP standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. Long-term storage under inert atmosphere (e.g., nitrogen or argon) is recommended for optimal preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.