Description

tert-Butyldimethylsilyl (S)-(-)-Glycidyl Ether is a high-value, chiral organosilicon compound widely used as a key chiral building block in advanced organic synthesis. Its primary value lies in its ability to introduce a protected, enantiomerically pure glycidol moiety into target molecules, enabling the stereoselective construction of complex pharmacophores. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiomerically pure β-blockers, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used in the preparation of chiral epoxides and 1,2-diols via regioselective ring-opening reactions for complex molecule construction.
• Agrochemical Development: Serves as a building block for creating chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Liquid Crystal & Polymer Chemistry: Employed in the synthesis of chiral dopants for liquid crystal displays (LCDs) and specialty polymers with tailored properties.
• Protecting Group Strategy: The TBDMS group provides robust protection for alcohols; the glycidyl ether can be further functionalized and deprotected in multi-step syntheses.
• Chemical Biology & Probe Development: Useful for labeling and modifying biomolecules or creating activity-based probes due to its reactive epoxide ring.

Basic Information

Item	Detail
Product Name	tert-Butyldimethylsilyl (S)-(-)-Glycidyl Ether
CAS No.	123237-62-7
Molecular Formula	C9H20O2Si
Molecular Weight	188.34 g/mol
Synonyms	(S)-(-)-tert-Butyldimethylsilyl Glycidyl Ether; (S)-(-)-TBDMS Glycidyl Ether; (S)-Glycidyl tert-Butyldimethylsilyl Ether; (2S)-(-)-2-[(tert-Butyldimethylsilyl)oxymethyl]oxirane; (S)-(-)-1,2-Epoxy-3-[(tert-butyldimethylsilyl)oxy]propane; (S)-TBDMSO Glycidyl Ether; (S)-TBDS Glycidyl Ether
EINECS	Contact for details

Quality Control

Our tert-Butyldimethylsilyl (S)-(-)-Glycidyl Ether is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis by HPLC or GC, to ensure high enantiomeric excess (ee) and chemical purity. A detailed Certificate of Analysis (COA) providing specifications for identity, assay, chiral purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Enantiomeric Excess)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.