Description

(-)-(S,S)-trans-Tramadol is a specific stereoisomer of the centrally acting analgesic tramadol, distinguished by its unique spatial configuration. This high-purity enantiomer is critical for advanced pharmaceutical research and development, particularly in studies focused on receptor selectivity, metabolic pathways, and the synthesis of novel active pharmaceutical ingredients (APIs). It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require precise chiral compounds for drug discovery and process development.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control testing of tramadol-based medications.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex pharmaceutical compounds.
• Metabolic and Pharmacokinetic Studies: Employed in research to investigate the stereoselective metabolism, distribution, and efficacy of tramadol isomers.
• Analytical Chemistry: Utilized as a high-purity standard for chromatography (HPLC, GC) and spectroscopy to ensure accurate quantification and identification.
• Medicinal Chemistry Research: Acts as a precursor or template for designing and synthesizing new chemical entities with potential analgesic activity.
• Regulatory Compliance and Testing: Essential for conducting impurity profiling and stability studies to meet regulatory requirements (e.g., FDA, EMA) for drug submissions.

Basic Information

Product Name	(-)-(S,S)-trans-Tramadol
CAS No.	123134-25-8
Molecular Formula	C16H25NO2
Molecular Weight	263.38 g/mol
Synonyms	(1S,2S)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol; (-)-trans-Tramadol; (S,S)-Tramadol; Tramadol (S,S)-(-)-isomer; (1S,2S)-Tramadol; UNII-1J2J0F391C; (S,S)-(-)-Tramadol; Tramadol Impurity F (EP)
EINECS	Contact for details

Quality Control

Our (-)-(S,S)-trans-Tramadol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets exacting standards for research and development use. A detailed Certificate of Analysis (COA) providing full characterization data—including identity, assay, chiral purity, and impurity profile—is supplied with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the product should be handled in a low-humidity environment and the container kept sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.