Description

Modipafant is a selective and potent platelet-activating factor (PAF) receptor antagonist. This compound is a critical research tool for investigating inflammatory pathways, bronchoconstriction, and anaphylaxis. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and academic institutions engaged in preclinical drug discovery and pharmacological studies for respiratory and inflammatory conditions.

Application

• Pharmacological Research: As a reference standard in studies targeting the PAF receptor to understand its role in various disease models.
• Inflammatory Disease Studies: For investigating conditions like asthma, sepsis, and shock where PAF is a key mediator.
• Drug Discovery & Development: Serving as a lead compound or benchmark for developing novel anti-inflammatory therapeutics.
• Biochemical Assay Development: Used in high-throughput screening (HTS) and binding assays to identify and characterize new PAF antagonists.
• Academic Research: A vital reagent for university labs studying cell signaling, receptor biology, and inflammatory cascades.
• Preclinical Testing: Evaluation of efficacy and mechanism of action in animal models of inflammation and allergy.

Basic Information

Product Name	Modipafant
CAS No.	122957-06-6
Molecular Formula	C24H28N2O5S
Molecular Weight	456.56 g/mol
Synonyms	UK-80,067; UK 80067; UK80067; 4-[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-butanone; (R)-4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl 1-morpholinobutan-1-one
EINECS	Contact for details

Quality Control

Our Modipafant is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.