Description

Phoslactomycin C is a potent, naturally occurring antibiotic and antitumor agent belonging to the leptomycin family. This compound matters for its unique mechanism of action, primarily functioning as a potent inhibitor of nuclear export signal (NES)-dependent protein transport, making it a critical research tool in cell biology and oncology. Researchers and pharmaceutical developers in the fields of cancer research, molecular biology, and drug discovery require this high-purity biochemical for investigating signal transduction pathways and developing novel therapeutic strategies.

Application

• Biomedical Research: Used as a specific and potent inhibitor of CRM1/exportin 1 (XPO1) to study nuclear-cytoplasmic transport of proteins and RNA.
• Oncology & Cancer Research: Investigated for its antitumor properties and its role in inducing apoptosis in various cancer cell lines.
• Signal Transduction Studies: A key tool for elucidating pathways involving transcription factors (e.g., NF-κB, p53) whose localization is regulated by nuclear export.
• Virology Research: Used to study the life cycle of viruses that rely on host nuclear export machinery.
• Drug Discovery & Development: Serves as a lead compound or a pharmacological probe in the development of novel anticancer agents targeting nuclear export.
• Cell Biology & Biochemistry: Employed in experiments to understand cell cycle regulation, stress response, and protein trafficking.

Basic Information

Product Name	Phoslactomycin C
CAS No.	122856-27-3
Molecular Formula	C₂₄H₃₅NO₈
Molecular Weight	465.54 g/mol
Synonyms	Leptomycin C; LMB-C; (2E,4E,6R,7S,8E)-7-[(2S,3S,4S,5S)-3,4-Dihydroxy-5-[(1E,3E)-4-[(2S,3S,4S,5S)-3,4-dihydroxy-5-methyloxolan-2-yl]buta-1,3-dienyl]oxolan-2-yl]-2,4,8-trimethyldeca-2,4,8-trienoic acid; Antibiotic BE-14106; Phoslactomycin
EINECS	Contact for details

Quality Control

Our Phoslactomycin C is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) documenting identity, purity, and potency is provided with every shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Biological Activity	Assayed (IC50 for nuclear export inhibition)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.