Description

3-Hydroxypropionitrile-2,2,3,3-D4 is a deuterium-labeled isotopologue of 3-hydroxypropionitrile, a valuable building block in organic synthesis. This high-purity labeled compound is essential for research and development in analytical chemistry, particularly for use as an internal standard in mass spectrometry to ensure accurate quantification. It is primarily utilized by pharmaceutical, agrochemical, and advanced material scientists engaged in metabolic studies, tracer analysis, and the synthesis of deuterated target molecules. The product offers critical advantages in method validation and the study of reaction mechanisms where isotopic tracking is required.

Application

• Internal Standard for LC/MS & GC/MS Analysis: Provides precise quantification in bioanalytical and pharmacokinetic studies due to its isotopic purity.
• Deuterated Building Block: Used in the synthesis of more complex deuterium-labeled pharmaceuticals and fine chemicals.
• Metabolic Pathway Tracing: Aids in drug metabolism and disposition (DMPK) studies within pharmaceutical R&D.
• NMR Spectroscopy: Serves as a useful probe in mechanistic and structural analysis without interfering with the spectral region of interest.
• Chemical Research: Employed in academic and industrial labs for investigating reaction kinetics and mechanisms using isotopic labeling techniques.

Basic Information

Product Name	3-Hydroxypropionitrile-2,2,3,3-D4
CAS No.	122775-18-2
Molecular Formula	C₃H₂D₄NO
Molecular Weight	90.12 g/mol
Synonyms	3-Hydroxypropionitrile-d4; 2,2,3,3-Tetradeutero-3-hydroxypropionitrile; 3-Hydroxypropanenitrile-2,2,3,3-d4; β-Hydroxypropionitrile-d4; Hydracrylonitrile-d4; Ethylene cyanohydrin-d4; Deuterated 3-Hydroxypropionitrile
EINECS	Contact for details

Quality Control

Our 3-Hydroxypropionitrile-2,2,3,3-D4 is manufactured under strict quality control protocols to ensure high isotopic and chemical purity suitable for sensitive analytical applications. Each batch is characterized by advanced spectroscopic methods, including NMR and Mass Spectrometry, to confirm deuteration level and identity. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles are provided to guarantee traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.