Description

(S)-Tetrahydro-1H-Pyrrolo[1,2-C]Imidazol-3(2H)-One is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is valued for its rigid, bicyclic imidazolidinone structure, which serves as a key scaffold in modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers in the development of novel therapeutic agents, particularly for central nervous system (CNS) and metabolic disorder targets.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of potent, selective drug candidates.
• Asymmetric Catalysis: Used as a precursor or ligand framework in the development of novel chiral catalysts.
• Medicinal Chemistry Research: Serves as a privileged scaffold for constructing compound libraries in high-throughput screening (HTS) campaigns.
• Protease Inhibitor Development: Its constrained structure is applicable in designing inhibitors for various protease enzymes.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	(S)-Tetrahydro-1H-Pyrrolo[1,2-C]Imidazol-3(2H)-One
CAS No.	122481-21-4
Molecular Formula	C7H10N2O
Molecular Weight	138.17 g/mol
Synonyms	(S)-Hexahydropyrrolo[1,2-c]imidazol-3-one; (3S)-2,3,5,6,7,7a-Hexahydro-1H-pyrrolo[1,2-c]imidazol-3-one; (S)-1,2,3,5,6,7-Hexahydropyrrolo[1,2-c]imidazol-3-one; (S)-Pyrroloimidazolidinone; L-Hexahydropyrroloimidazolone; (S)-THPI; (S)-Enantiomer of Pyrrolo[1,2-c]imidazol-3-one
EINECS	Contact for details

Quality Control

Our (S)-Tetrahydro-1H-Pyrrolo[1,2-C]Imidazol-3(2H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.