Description

Hemibrevetoxin B CAS NO 122271-91-4 is a marine neurotoxin and a key structural analog of the brevetoxin family, isolated from the dinoflagellate *Karenia brevis*. This compound is of significant value as a high-purity reference standard and a critical research tool for studying sodium channel function and the mechanisms of neurotoxic shellfish poisoning. It is essential for researchers and quality control laboratories in the fields of marine toxicology, pharmacology, and environmental monitoring who require reliable, well-characterized analytical standards.

Application

• Marine Toxin Research: Serves as a primary reference standard for the identification and quantification of brevetoxins in environmental and biological samples.
• Pharmacological Studies: Used as a selective probe to investigate voltage-gated sodium channel (VGSC) modulation, receptor binding, and neurotoxic pathways.
• Food Safety & Regulatory Testing: Critical for developing and validating analytical methods (e.g., LC-MS/MS) to monitor shellfish toxicity and ensure seafood safety compliance.
• Biomedical Research: Employed in studies exploring the physiological effects and potential therapeutic targets related to neurotoxin exposure.
• Environmental Monitoring: Used to calibrate equipment and confirm the presence of *Karenia brevis* blooms in water samples.
• Diagnostic Development: Acts as a key antigen or standard in the development of immunoassays and biosensors for rapid toxin detection.

Basic Information

Product Name	Hemibrevetoxin B
CAS No.	122271-91-4
Molecular Formula	C50H70O13
Molecular Weight	878.1 g/mol
Synonyms	Hemibrevetoxin B; Brevetoxin B2; PbTx-2B; (2S)-2-[(1R,2S,3S,4R,7S,9S,10S,12R,14S,15R,17S,19S,20R,21S,23S,24R,26S,28R,29S,31R,33S,34R,36S,37R,39S,40R,42S,43R,45S,46R,48S,49R,51S,52R,54S,55R,57S,58R,60S,61R,63S,64R,66S,67R,69S,70R,72S,73R,75S,76R)-2,4,7,9,12,14,17,19,21,23,26,28,31,33,36,39,42,45,48,51,54,57,60,63,66,69,72,75-Octacosaacetoxy-1,3,5,8,10,13,15,18,20,22,24,27,29,32,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76-nonacosaoxooctacontyl]oxy]propanoic acid
EINECS	Contact for details

Quality Control

Our Hemibrevetoxin B is produced and handled under strict quality protocols to ensure identity, purity, and stability for critical research applications. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identification, and impurity profiles is provided to guarantee traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.