Description

Bis(2-(Trimethylsilyl)Ethyl) Diisopropylphosphoramidite is a highly specialized organophosphorus reagent featuring silyl-protected hydroxyl groups. This compound matters as a critical building block in the synthesis of complex molecules, particularly in oligonucleotide and pharmaceutical manufacturing, where it acts as a phosphitylating agent. It is essential for researchers and production chemists in the fields of nucleic acid synthesis, agrochemical development, and advanced material science who require high-purity, moisture-sensitive intermediates for precise coupling reactions.

Application

• Phosphoramidite Monomer in Oligonucleotide Synthesis: A key reagent for the solid-phase synthesis of DNA, RNA, and their analogs, enabling the controlled assembly of nucleotide chains.
• Pharmaceutical Intermediate: Used in the preparation of prodrugs and nucleotide-based therapeutics, including antiviral and anticancer agents.
• Agrochemical Synthesis: Serves as a precursor in creating novel pesticides and herbicides with specific activity profiles.
• Ligand and Catalyst Preparation: Employed in the development of chiral phosphine ligands for asymmetric catalysis.
• Material Science Research: Utilized in the surface functionalization of silicon-based materials and the synthesis of specialized polymers.
• Process Development & Scale-Up: A critical raw material for process chemistry teams optimizing routes for active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	Bis(2-(Trimethylsilyl)Ethyl) Diisopropylphosphoramidite
CAS No.	121373-20-4
Molecular Formula	C16H40NO2PSi2
Molecular Weight	365.65 g/mol
Synonyms	Diisopropyl [Bis(2-trimethylsilylethoxy)]phosphine; Diisopropylphosphoramidous Acid Bis(2-(Trimethylsilyl)Ethyl) Ester; 2-[Bis(2-trimethylsilylethoxy)phosphino]oxy-N-(propan-2-yl)propan-2-amine; (i-Pr)2NP(OC2H4SiMe3)2; TMS-ethyl protected diisopropylphosphoramidite; Phosphoramidite reagent CAS 121373-20-4
EINECS	Contact for details

Quality Control

Our Bis(2-(Trimethylsilyl)Ethyl) Diisopropylphosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including NMR (¹H, ³¹P), HPLC, and Karl Fischer titration, to verify identity, purity, and moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen). Due to its hygroscopic and moisture-sensitive nature, the container must be purged with inert gas after each opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.1%
³¹P NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.