Description

Misonidazole-D3 is a deuterated isotopologue of the nitroimidazole radiosensitizer, misonidazole, where three hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential for advanced pharmacokinetic and metabolic studies, providing critical insights into drug behavior without altering its biological activity. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and academic institutions engaged in the development and analysis of radiosensitizing agents and hypoxia-targeting therapeutics.

Application

• Internal standard for the precise quantification of misonidazole in biological matrices using LC-MS/MS and GC-MS analytical methods.
• Tracer compound in drug metabolism and pharmacokinetics (DMPK) studies to investigate absorption, distribution, metabolism, and excretion (ADME) pathways.
• Critical reagent in the research of hypoxia-selective cytotoxins and radiosensitizers for oncology applications.
• Use in deuterium labeling studies to explore isotope effects on drug stability and metabolic fate.
• Reference material for quality control and method validation in pharmaceutical development and regulatory submissions.

Basic Information

Product Name	Misonidazole-D3
CAS No.	121244-83-5
Molecular Formula	C7H8D3N3O4
Molecular Weight	202.18 g/mol
Synonyms	1-(2-Nitro-1-imidazolyl)-3-methoxy-2-propanol-D3; 2-Nitro-1-(3-methoxy-2-hydroxypropyl)imidazole-D3; MISO-D3; Misonidazole (deuterated); [2H3]-Misonidazole; Ro-07-0582-D3; NSC 261037-D3
EINECS	Contact for details

Quality Control

Every batch of Misonidazole-D3 is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and isotopic enrichment meet the exacting standards required for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.