Description

(-)-6-8-Difluoro-2,3,4,9-Tetrahydro-9-[[4-(Methylsulfonyl)Phenyl]Methyl]-1H-Carbazole-1-Acetic Acid is a high-purity, non-racemic chiral compound that serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its value lies in its complex, functionalized carbazole core, which is essential for developing novel therapeutic agents with targeted biological activity. This product is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex molecules for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) due to its fluorinated carbazole scaffold.
• Asymmetric Synthesis: Employed as a chiral precursor or reagent in stereoselective synthesis to introduce complex molecular architectures with high enantiomeric purity.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Biochemical Research: Potential use as a probe or inhibitor in biochemical assays to study enzyme interactions and signaling pathways.
• Fine Chemical Synthesis: Utilized in the multi-step synthesis of specialty chemicals, agrochemicals, and other fluorinated organic compounds.

Basic Information

Item	Details
Product Name	(-)-6-8-Difluoro-2,3,4,9-Tetrahydro-9-[[4-(Methylsulfonyl)Phenyl]Methyl]-1H-Carbazole-1-Acetic Acid
CAS No.	121083-05-4
Molecular Formula	C22H21F2NO4S
Molecular Weight	433.47 g/mol
Synonyms	(-)-6,8-Difluoro-2,3,4,9-tetrahydro-9-[(4-methylsulfonylphenyl)methyl]-1H-carbazole-1-acetic acid; 9-[(4-Methanesulfonylphenyl)methyl]-6,8-difluoro-2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid; (9S)-6,8-Difluoro-9-[(4-methylsulfonylphenyl)methyl]-2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid; 121083-05-4; UNII-8J6K6G5J8Q; SCHEMBL218422; Carbazole-1-acetic acid, 6,8-difluoro-2,3,4,9-tetrahydro-9-[[4-(methylsulfonyl)phenyl]methyl]-, (9S)-
EINECS	Contact for details

Quality Control

Our (-)-6-8-Difluoro-2,3,4,9-Tetrahydro-9-[[4-(Methylsulfonyl)Phenyl]Methyl]-1H-Carbazole-1-Acetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, NMR, and mass spectrometry for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.