Description

Desfuroyl Ceftiofur S-Acetamide is a key intermediate and metabolite in the synthesis and analysis of the third-generation cephalosporin antibiotic, ceftiofur. This compound is of critical importance for pharmaceutical research and development, particularly in the veterinary medicine sector, where ceftiofur is widely used. It serves as an essential reference standard and building block for manufacturers and analytical laboratories focused on antimicrobial drug development and quality control. Professionals in pharmaceutical synthesis, analytical chemistry, and veterinary drug manufacturing rely on this high-purity intermediate.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of ceftiofur and its metabolites in biological samples and finished products.
• Active Pharmaceutical Ingredient (API) Intermediate: A crucial synthetic precursor in the multi-step manufacturing process of ceftiofur sodium and other ceftiofur salts.
• Metabolite Studies: Essential for pharmacokinetic and residue depletion studies in animals to establish withdrawal times and ensure food safety.
• Analytical Method Development: Serves as a standard for developing and validating HPLC, LC-MS/MS, and other chromatographic methods in quality control laboratories.
• Veterinary Drug Research: Used in R&D for developing new formulations and delivery systems of cephalosporin-based antibiotics for livestock and companion animals.
• Impurity Profiling: Employed to identify and quantify related substances and degradation products in ceftiofur API and formulated drug products.

Basic Information

Product Name	Desfuroyl Ceftiofur S-Acetamide
CAS No.	120882-25-9
Molecular Formula	C20H22N6O7S3
Molecular Weight	554.63 g/mol
Synonyms	(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[(acetylthio)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Desfuroylceftiofur Acetamide; Ceftiofur Metabolite; 7β-[2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-(acetamidomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Desfuroyl Ceftiofur Acetamide Derivative
EINECS	Contact for details

Quality Control

Our Desfuroyl Ceftiofur S-Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets high-purity standards suitable for pharmaceutical R&D and analysis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.