Description

2-(4-Piperidinylmethyl)-1,2,3,4-Tetrahydroisoquinoline Dihydrochloride is a high-purity, pharmaceutically relevant organic salt, primarily utilized as a sophisticated chemical intermediate in advanced synthesis. Its core value lies in enabling the development of novel therapeutic agents, particularly within the central nervous system (CNS) and receptor-targeting drug discovery pipelines. This compound is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules and potential active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting neurological and psychiatric disorders.
• Chemical Research & Development: Used in academic and industrial R&D for exploring new synthetic pathways and creating libraries of bioactive compounds.
• Ligand Synthesis: Serves as a precursor for developing specific ligands targeting receptors within the CNS, such as sigma receptors or other G-protein-coupled receptors (GPCRs).
• Preclinical Studies: Employed in the preparation of compounds for pharmacological evaluation, metabolism studies, and toxicity profiling.
• Process Chemistry: Used in scale-up and optimization studies for the commercial production of potential therapeutic agents.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	2-(4-Piperidinylmethyl)-1,2,3,4-Tetrahydroisoquinoline Dihydrochloride
CAS No.	120847-08-7
Molecular Formula	C15H22N2 · 2HCl
Molecular Weight	311.27 g/mol (Free base: 230.35 g/mol)
Synonyms	1,2,3,4-Tetrahydro-2-[(4-piperidinyl)methyl]isoquinoline Dihydrochloride; 2-(Piperidin-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline Dihydrochloride; 2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydroisoquinoline Dihydrochloride; 2-(4-Piperidylmethyl)-1,2,3,4-tetrahydroisoquinoline Dihydrochloride; THIQ-Piperidine Dihydrochloride Derivative; CAS 120847-08-7
EINECS	Contact for details

Quality Control

Our 2-(4-Piperidinylmethyl)-1,2,3,4-Tetrahydroisoquinoline Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.