Description

3-tert-Butyldimethylsilyl-2-Propyn-1-Ol is a versatile organosilicon-protected propargylic alcohol, a key building block in advanced organic synthesis. Its primary value lies in its role as a protected intermediate, allowing for selective chemical transformations in complex molecule construction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of advanced pesticides, herbicides, and plant growth regulators.
• Material Science Research: Serves as a precursor for novel polymers, dendrimers, and functionalized materials with specific properties.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products requiring selective protection and deprotection strategies.
• Ligand and Catalyst Development: Used to create novel ligands and organometallic catalysts for asymmetric synthesis.

Basic Information

Product Name	3-tert-Butyldimethylsilyl-2-Propyn-1-Ol
CAS No.	120789-51-7
Molecular Formula	C9H18OSi
Molecular Weight	170.32 g/mol
Synonyms	3-[(1,1-Dimethylethyl)dimethylsilyl]-2-propyn-1-ol; 3-(tert-Butyldimethylsilyl)prop-2-yn-1-ol; TBDMS-Propargyl Alcohol; (tert-Butyldimethylsilyl)propargyl Alcohol; 2-Propyn-1-ol, 3-[(1,1-dimethylethyl)dimethylsilyl]-; 3-(tert-Butyldimethylsiloxy)-1-propyne; 3-TBDMS-2-propyn-1-ol
EINECS	Contact for details

Quality Control

Our 3-tert-Butyldimethylsilyl-2-Propyn-1-Ol is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each batch, detailing key parameters such as identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.