Description

7-Chloro-8-Hydroxy-1-(4'-Iodophenyl)-3-Methyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine is a high-purity, synthetically derived benzazepine derivative, serving as a critical advanced intermediate in modern pharmaceutical research and development. Its complex molecular architecture, featuring chloro, hydroxy, and iodophenyl substituents, makes it a valuable scaffold for constructing novel bioactive compounds. This compound is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly within the central nervous system (CNS) and receptor-targeted drug discovery sectors.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates targeting neurological and psychiatric disorders.
• Research Chemical: Used in academic and industrial research for studying benzazepine pharmacology and structure-activity relationships (SAR).
• Precursor for Radioligands: The iodine atom provides a potential site for radiolabeling (e.g., with I-125), making it useful in developing diagnostic imaging agents.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in API manufacturing.
• Medicinal Chemistry: Employed in the design and synthesis of compounds for high-throughput screening (HTS) against various biological targets.

Basic Information

Product Name	7-Chloro-8-Hydroxy-1-(4'-Iodophenyl)-3-Methyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine
CAS No.	120685-95-2
Molecular Formula	C17H17ClINO
Molecular Weight	413.68 g/mol
Synonyms	1-(4-Iodophenyl)-7-chloro-8-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 7-Chloro-8-hydroxy-1-(4-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 1-(4'-Iodophenyl)-7-chloro-8-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; CAS 120685-95-2; 3-Benzazepine, 7-chloro-8-hydroxy-1-(4-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-; 7-Chloro-1-(4-iodophenyl)-8-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
EINECS	Contact for details

Quality Control

Our 7-Chloro-8-Hydroxy-1-(4'-Iodophenyl)-3-Methyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.