Description

Trefentanil is a potent synthetic opioid analgesic belonging to the 4-anilidopiperidine class. Its high potency and selectivity for the mu-opioid receptor make it a compound of significant interest in advanced pharmacological research and development. This product is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard providers, and specialized chemical manufacturers engaged in the synthesis of controlled substances for medical or forensic science applications.

Application

• Pharmacological Research: Used as a reference standard or active pharmaceutical ingredient (API) in preclinical studies investigating opioid receptor activity, analgesic efficacy, and structure-activity relationships (SAR).
• Analytical Reference Standard: Serves as a high-purity certified reference material (CRM) for qualitative and quantitative analysis in forensic toxicology, drug testing, and regulatory compliance laboratories.
• Chemical Synthesis Intermediate: Employed in the controlled synthesis of novel opioid analogs or labeled compounds for tracer studies within secure, licensed manufacturing facilities.
• Biomedical Research: Applied in vitro and in vivo studies to explore pain pathways, neurotransmitter systems, and the development of opioid tolerance or dependence.

Basic Information

Product Name	Trefentanil
CAS No.	120656-74-8
Molecular Formula	C24H30N2O3
Molecular Weight	394.51 g/mol
Synonyms	Trefentanil; 1-Phenethyl-4-(N-phenylpropionamido)piperidine-4-carboxylic acid methyl ester; Methyl 1-(2-phenylethyl)-4-(phenylpropionylamino)piperidine-4-carboxylate; 4-Carbomethoxyfentanyl; Fentanyl analog; R-31,633; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Trefentanil is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods and purity determination by chromatographic techniques. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.