Description

Anastrozole-D12 is a deuterium-labeled analog of the aromatase inhibitor anastrozole, specifically designed for use as an internal standard in quantitative bioanalytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and precision in mass spectrometry-based analyses, particularly in pharmacokinetic and metabolism studies. It is a critical tool for pharmaceutical research and development laboratories, clinical testing facilities, and contract research organizations (CROs) requiring reliable quantification of anastrozole in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays for anastrozole.
• Pharmacokinetic (PK) Studies: Enables precise measurement of drug concentration over time in plasma, serum, and other biological fluids.
• Bioequivalence and Bioavailability Studies: Critical for comparative analysis of drug formulations in clinical trials.
• Drug Metabolism and Disposition (DMPK): Used in studies investigating the absorption, distribution, metabolism, and excretion (ADME) of anastrozole.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of assays to monitor anastrozole levels in patient samples for personalized medicine in oncology.
• Forensic and Anti-Doping Analysis: Can be utilized in specialized testing protocols requiring high specificity and accuracy.

Basic Information

Product Name	Anastrozole-D12
CAS No.	120512-32-5
Molecular Formula	C17D12H7N5
Molecular Weight	306.38 g/mol
Synonyms	Anastrozole-d12; 2,2'-[5-((1H-1,2,4-Triazol-1-yl)methyl)-1,3-phenylene]bis(2-methylpropiononitrile)-d12; Arimidex-d12; ZD1033-d12; 1,3-Benzenediacetonitrile-d12, α,α,α',α'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-; Deuterated Anastrozole; Anastrozole (phenyl-d12)
EINECS	Contact for details

Quality Control

Every batch of Anastrozole-D12 is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support its use in regulated environments, including Certificates of Analysis (COA) detailing isotopic purity, chemical purity, and identity confirmation. Our quality commitment ensures the material meets the stringent requirements for internal standard applications in bioanalytical method development and validation per ICH and FDA guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 99.0 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.