Description

(4-(Bromomethyl)Phenoxy)(tert-Butyl)Dimethylsilane is a versatile organosilicon reagent featuring a bromomethylphenoxy group protected by a tert-butyldimethylsilyl (TBDMS) ether. This compound matters as a key synthetic intermediate, offering a protected phenolic functionality that can be selectively deprotected and further functionalized via the reactive benzyl bromide moiety. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures, particularly in nucleoside and carbohydrate chemistry.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), especially for introducing protected phenol units into drug candidates.
• Nucleoside & Nucleotide Chemistry: Serves as a key building block for modifying sugar moieties and creating novel nucleoside analogs for antiviral or anticancer research.
• Agrochemical Synthesis: Employed in the development of advanced herbicides, fungicides, and plant growth regulators requiring specific phenolic ether structures.
• Polymer & Material Science: Acts as a monomer or cross-linking agent in the production of specialty silicones and functional polymers.
• Ligand & Catalyst Development: Useful for synthesizing sophisticated ligands for metal catalysis and organocatalysts.
• Protecting Group Strategy: The TBDMS group provides a robust protecting group for phenols, which can be cleaved under specific conditions without affecting other sensitive functionalities.
• Chemical Biology Probes: Facilitates the creation of bioconjugates and molecular probes for studying biological processes.

Basic Information

Product Name	(4-(Bromomethyl)Phenoxy)(tert-Butyl)Dimethylsilane
CAS No.	120506-39-0
Molecular Formula	C13H21BrOSi
Molecular Weight	301.30 g/mol
Synonyms	4-[(tert-Butyldimethylsilyl)oxy]benzyl bromide; 1-[(tert-Butyldimethylsilyl)oxy]-4-(bromomethyl)benzene; p-[(tert-Butyldimethylsilyl)oxy]benzyl bromide; 4-(Bromomethyl)phenyl tert-butyldimethylsilyl ether; TBDMS ether of 4-(bromomethyl)phenol; tert-Butyl(4-(bromomethyl)phenoxy)dimethylsilane; 4-(Bromomethyl)phenol TBDMS ether; Silane, [4-(bromomethyl)phenoxy](1,1-dimethylethyl)dimethyl-
EINECS	Contact for details

Quality Control

Our (4-(Bromomethyl)Phenoxy)(tert-Butyl)Dimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.