Description

5-Acetyl-2-Hydroxy-4-Methylthiophene-3-Carbonitrile is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring acetyl, hydroxyl, and nitrile groups on a thiophene core, makes it a versatile precursor for constructing complex pharmacophores and functional materials. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the synthesis of advanced pesticides, herbicides, and fungicides, leveraging its thiophene-based structure for bioactivity.
• Material Science Research: Serves as a building block for organic electronic materials, such as conductive polymers or organic semiconductors, due to the electron-rich thiophene unit.
• Dye and Pigment Precursor: Utilized in the synthesis of specialized dyes and pigments where the thiophene ring contributes to color and stability properties.
• Chemical Research & Development: Employed as a versatile starting material for novel organic reactions and methodology development in academic and industrial R&D labs.
• Ligand and Catalyst Development: The functional groups can be modified to create novel chelating ligands for metal catalysis.

Basic Information

Item	Detail
Product Name	5-Acetyl-2-Hydroxy-4-Methylthiophene-3-Carbonitrile
CAS No.	120456-32-8
Molecular Formula	C8H7NO2S
Molecular Weight	181.21 g/mol
Synonyms	3-Cyano-5-acetyl-2-hydroxy-4-methylthiophene; 2-Hydroxy-4-methyl-5-acetylthiophene-3-carbonitrile; 5-Acetyl-2-hydroxy-4-methyl-3-thiophenecarbonitrile; 4-Methyl-5-acetyl-2-hydroxythiophene-3-carbonitrile; 3-Thiophenecarbonitrile, 5-acetyl-2-hydroxy-4-methyl-; 2-Hydroxy-4-methyl-5-acetyl-3-thiophenecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 5-Acetyl-2-Hydroxy-4-Methylthiophene-3-Carbonitrile is manufactured and tested under a strict quality management system. We ensure high chemical purity and consistency through advanced analytical techniques including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. The container must be kept tightly closed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.