Description

Verlukast is a potent and selective leukotriene receptor antagonist with the CAS registry number 120443-16-5. This compound is of significant interest in pharmaceutical research and development, particularly for its potential role in modulating inflammatory pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of new therapeutic agents for respiratory and inflammatory conditions.

Application

• Pharmaceutical Research & Development: A key intermediate or reference standard in the synthesis and study of novel leukotriene receptor antagonists.
• Biochemical Assays: Used as a pharmacological tool to investigate leukotriene D4 (LTD4) receptor binding and signal transduction in vitro.
• Preclinical Studies: Employed in animal models to evaluate efficacy and pharmacokinetics for potential asthma and allergy treatments.
• Mechanism of Action Studies: Serves as a reference compound to understand the pathophysiology of inflammatory diseases mediated by cysteinyl leukotrienes.
• Analytical Standard: Used as a high-purity standard for method development and quality control (HPLC, LC-MS) in analytical laboratories.

Basic Information

Product Name	Verlukast
CAS No.	120443-16-5
Molecular Formula	C31H33N3O6S
Molecular Weight	575.68 g/mol
Synonyms	Verlukast; L-660,711; MK-571; (R)-(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic Acid; L 660711; MK 571; L-660711; (R,E)-3-((3-(2-(7-Chloroquinolin-2-yl)vinyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methylthio)propanoic Acid
EINECS	Contact for details

Quality Control

Our Verlukast is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets stringent specifications for research use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (typically 15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.