Description

3,4-Difluoro-1H-Pyrrole is a fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel pharmaceuticals and agrochemicals, where the introduction of fluorine atoms can dramatically alter biological activity and metabolic stability. It is primarily needed by research institutions and industrial R&D departments focused on medicinal chemistry, material science, and the synthesis of complex, high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical scaffold in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, where fluorinated pyrroles enhance efficacy and environmental profile.
• Material Science Precursor: Employed in the creation of advanced organic electronic materials, such as conductive polymers and organic light-emitting diodes (OLEDs).
• Ligand and Catalyst Development: Acts as a starting material for synthesizing novel fluorinated ligands used in catalysis and asymmetric synthesis.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research exploring new fluorination methodologies and the properties of fluorinated heterocycles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for client projects.

Basic Information

Product Name	3,4-Difluoro-1H-Pyrrole
CAS No.	120047-51-0
Molecular Formula	C4H3F2N
Molecular Weight	103.07 g/mol
Synonyms	3,4-Difluoropyrrole; 3,4-Difluoro-1H-pyrrole; 1H-Pyrrole, 3,4-difluoro-; Difluoropyrrole; 3,4-Difluoropyrrole; 3,4-Difluoro-1H-azole
EINECS	Contact for details

Quality Control

Every batch of 3,4-Difluoro-1H-Pyrrole is produced and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its properties as a fluoride/strong alkali and high volatility, ensure containers are kept tightly sealed and away from incompatible materials. Handle and store under an inert atmosphere if specified for your grade.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.