Description

D,L-Carnitine-D3 Chloride is a deuterium-labeled isotopologue of the essential nutrient carnitine, specifically designed for research and analytical applications. This compound is crucial for metabolic studies, serving as an internal standard in mass spectrometry to ensure accurate quantification of carnitine and its derivatives in biological samples. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and analytical service providers engaged in metabolomics, pharmacokinetics, and biomarker discovery.

Application

• Internal Standard for LC-MS/MS Analysis: Essential for the precise and accurate quantification of L-carnitine and acetylcarnitine in complex biological matrices like plasma, serum, and urine.
• Metabolomics Research: Used in tracer studies to investigate fatty acid metabolism, mitochondrial function, and energy production pathways.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables reliable tracking of drug-induced changes in carnitine homeostasis during clinical trials.
• Diagnostic Assay Development: Serves as a critical component in the development and validation of high-throughput clinical diagnostic tests for metabolic disorders.
• Biomarker Discovery and Validation: Facilitates the identification and verification of carnitine-related biomarkers for various disease states.
• Stable Isotope Dilution Assays: Provides the reference material needed for the most accurate method of quantifying analytes in research settings.

Basic Information

Item	Detail
Product Name	D,L-Carnitine-D3 Chloride
CAS No.	119766-67-5
Molecular Formula	C7H12D3ClNO3
Molecular Weight	199.67 g/mol (for D3 isotopologue)
Synonyms	(±)-Carnitine-d3 chloride; DL-Carnitine-d3 hydrochloride; 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium-d3 chloride; Vitamin BT-d3 chloride; L-Carnitine-d3 chloride (racemic mixture); (R,S)-3-Hydroxy-4-(trimethylammonio-d3)butyrate chloride; Levocarnitine-d3 chloride (racemate); Carnitine Inner Salt-d3 chloride
EINECS	Contact for details

Quality Control

Our D,L-Carnitine-D3 Chloride is manufactured under strict quality systems to ensure high chemical and isotopic purity, which is critical for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay by HPLC, isotopic enrichment by NMR or MS, and limits for related substances and residual solvents. We adhere to cGMP principles for research chemicals, ensuring traceability, consistency, and reliability for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Isotopic Enrichment	≥ 98 atom % D (by MS or NMR)
Chemical Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.