Description

2,3,5,6-Tetradeuterio-4-Nitro-1-Oxidopyridin-1-Ium is a deuterium-labeled derivative of 4-nitropyridine N-oxide, a key intermediate and building block in advanced chemical synthesis. This compound matters for its role as a stable isotope-labeled internal standard, which is critical for ensuring accuracy and reliability in quantitative analytical methods like mass spectrometry. It is primarily needed by research scientists and process chemists in the pharmaceutical, agrochemical, and analytical chemistry industries for drug metabolism studies, pharmacokinetic research, and the development of novel deuterated active pharmaceutical ingredients (APIs).

Application

• Internal Standard for Mass Spectrometry: Used as a quantitative reference standard in LC-MS and GC-MS analysis for accurate measurement of its non-deuterated counterpart in complex biological matrices.
• Pharmaceutical Research & Development: Serves as a crucial intermediate in the synthesis of deuterium-labeled drug candidates for metabolism and stability studies (DMPK).
• Metabolic Pathway Tracing: Enables precise tracking of metabolic pathways and degradation products in preclinical and clinical research.
• Agrochemical Analysis: Employed in environmental and residue analysis of nitropyridine-based pesticides and herbicides.
• Chemical Synthesis Building Block: Acts as a specialized precursor for introducing deuterium atoms into more complex molecular architectures.
• NMR Spectroscopy: Useful as a probe in nuclear magnetic resonance studies due to the distinct properties of deuterium atoms.

Basic Information

Product Name	2,3,5,6-Tetradeuterio-4-Nitro-1-Oxidopyridin-1-Ium
CAS No.	119673-94-8
Molecular Formula	C5HD4N2O3
Molecular Weight	144.11 g/mol
Synonyms	4-Nitropyridine N-Oxide-d4; 4-Nitro-1-oxidopyridin-1-ium-2,3,5,6-d4; Deuterated 4-Nitropyridine N-Oxide; 4-Nitropyridine-2,3,5,6-d4 1-Oxide; 4-Nitro-d4-pyridine N-oxide; 4-Nitropyridine-d4 1-Oxide; 4-Nitropyridine N-Oxide (tetradeuterated); 4-NO-d4-PyO
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as chemical purity, isotopic enrichment (D-atom %), and impurity profile. We support compliance with cGMP and ISO 9001 standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0% (by MS)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.