Description

D-[1-2H]Ribose is a stable isotope-labeled analog of the essential pentose sugar, D-ribose, where a deuterium atom replaces the hydrogen at the 1-position. This precise labeling makes it a critical tool for advanced research in metabolic pathway tracing and nuclear magnetic resonance (NMR) spectroscopy studies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers working in the fields of metabolomics, isotope dilution mass spectrometry, and drug metabolism and pharmacokinetics (DMPK).

Application

• Metabolic Flux Analysis (MFA): Used as a stable isotope tracer to map and quantify intracellular metabolic pathways in biological systems.
• NMR Spectroscopy: Serves as a deuterated standard or probe for structural and dynamic studies of biomolecules, reducing signal interference.
• Mass Spectrometry (MS): Employed as an internal standard in quantitative LC-MS and GC-MS methods for accurate measurement of ribose and its metabolites.
• Drug Metabolism Research: Facilitates the study of the metabolic fate of nucleoside-based pharmaceuticals and prodrugs.
• Biochemical Research: A key reagent in enzymatic studies and the synthesis of labeled nucleotides, nucleosides, and other biomolecules.
• Diagnostic Development: Potential use in developing clinical assays for inborn errors of metabolism related to pentose phosphate pathway disorders.

Basic Information

Product Name	D-[1-2H]Ribose
CAS No.	119540-50-0
Molecular Formula	C5H9D1O5
Molecular Weight	151.13 g/mol
Synonyms	1-Deuterio-D-ribose; D-Ribose-1-d; Deuterated D-ribose; (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal-1-d; 1-2H-D-Ribose; D-Ribose (1-2H); Stable Isotope Labeled D-Ribose; Ribose-d1
EINECS	Contact for details

Quality Control

Our D-[1-2H]Ribose is produced under controlled conditions to ensure high isotopic and chemical purity, meeting the stringent requirements of analytical and research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % 2H), chemical purity, and specific optical rotation. We adhere to rigorous internal quality standards to ensure batch-to-batch consistency and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 2H)	≥ 98%
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.