Description

2-Cyanoethyl 3-[[(4-Methoxyphenyl)Diphenylmethyl]Amino]Propyl N,n-Bis(1-Methylethyl)Phosphoramidite is a highly specialized phosphoramidite monomer, a critical building block in automated oligonucleotide synthesis. This compound is essential for the controlled, stepwise assembly of DNA and RNA sequences, enabling the production of primers, probes, and therapeutic oligonucleotides. It is primarily utilized by research institutions, diagnostic developers, and pharmaceutical companies engaged in genomics, molecular diagnostics, and the development of advanced nucleic acid-based therapeutics.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated synthesis of DNA and RNA strands.
• Therapeutic Oligonucleotide Manufacturing: Production of antisense oligonucleotides (ASOs), siRNA, and aptamers for pharmaceutical applications.
• Diagnostic Probe Synthesis: Manufacture of labeled and unlabeled DNA probes for PCR, qPCR, FISH, and microarray technologies.
• Primer Production: Synthesis of custom primers for sequencing, cloning, and amplification techniques.
• Research & Development: Enabling novel nucleic acid chemistry and the development of modified oligonucleotides with enhanced properties.
• Scale-Up GMP Production: Sourcing of high-purity monomers for cGMP-compliant manufacturing of clinical-grade oligonucleotides.

Basic Information

Product Name	2-Cyanoethyl 3-[[(4-Methoxyphenyl)Diphenylmethyl]Amino]Propyl N,n-Bis(1-Methylethyl)Phosphoramidite
CAS No.	119462-97-4
Molecular Formula	C34H44N3O3P
Molecular Weight	573.70 g/mol
Synonyms	MMT-C3-Amino Phosphoramidite; 4-Monomethoxytrityl-3-aminopropyl Phosphoramidite; 3-[(4-Methoxyphenyl)diphenylmethyl]amino-1-propyl N,N-diisopropyl-2-cyanoethylphosphoramidite; MMT-Amino-C3-Phosphoramidite; Amino Modifier C3 Phosphoramidite (MMT protected); 3-(N-MMT-amino)propyl phosphoramidite; N-MMT-3-aminopropyl phosphoramidite
EINECS	Contact for details

Quality Control

Every batch of our phosphoramidite monomers is produced and tested under stringent quality systems to ensure high purity and consistency, critical for successful oligonucleotide synthesis. We provide comprehensive Certificates of Analysis (COA) detailing purity (by 31P NMR and HPLC), identity, and moisture content. Our quality commitment supports applications from research to cGMP manufacturing, with documentation tailored to meet regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at -20°C or below in a dry, moisture-free environment. Due to its hygroscopic and easily oxidized nature, the container should only be opened under anhydrous conditions and the material used promptly to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (31P NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (31P NMR)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.