Description

2-Thiophenecarbonitrile, 5-Acetyltetrahydro-, trans- (9Ci) is a specialized heterocyclic building block featuring a saturated tetrahydrothiophene ring system with acetyl and nitrile functional groups. This compound matters as a high-value intermediate for the synthesis of complex molecules, offering a unique stereochemical and functional handle for advanced chemical transformations. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and exploring new chemical spaces.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science Research: Serves as a precursor for functionalized polymers or organic electronic materials due to its sulfur-containing heterocycle and modifiable functional groups.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds or molecular probes for studying biological pathways and target engagement.
• Catalyst Ligand Development: The nitrile and acetyl groups can be transformed to create novel ligands for asymmetric catalysis and metal-organic frameworks.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses serving the life sciences sector with bespoke chemical entities.

Basic Information

Product Name	2-Thiophenecarbonitrile, 5-Acetyltetrahydro-, trans- (9Ci)
CAS No.	119292-53-4
Molecular Formula	C7H9NOS
Molecular Weight	155.22 g/mol
Synonyms	trans-5-Acetyl-2,3,4,5-tetrahydrothiophene-2-carbonitrile; 5-Acetyl-2,3,4,5-tetrahydrothiophene-2-carbonitrile, trans-; 2-Cyano-5-acetyltetrahydrothiophene, trans-; (2R,5R)-5-Acetyl-2,3,4,5-tetrahydrothiophene-2-carbonitrile (and its enantiomer); 5-Acetyltetrahydro-2-thiophenecarbonitrile, trans-; Tetrahydro-5-acetyl-2-thiophenecarbonitrile; ATHTCN
EINECS	Contact for details

Quality Control

Our 2-Thiophenecarbonitrile, 5-Acetyltetrahydro-, trans- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.