Description

2-Thiophenecarbonitrile, 5-Formyltetrahydro-, cis- (9Ci) is a high-purity, specialized heterocyclic building block featuring both nitrile and formyl functional groups on a saturated thiophene ring. This compound matters as a critical chiral synthon for the synthesis of complex, biologically active molecules, offering precise stereochemical control. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel drug candidates, advanced intermediates, and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the thiophene scaffold imparts specific biological activity.
• Ligand and Catalyst Synthesis: Employed in the preparation of specialized chiral ligands for asymmetric catalysis and organometallic complexes.
• Material Science Precursor: Acts as a monomer or functionalizing agent in the development of advanced polymers and organic electronic materials.
• Chemical Biology Probe Development: Utilized to create molecular probes and tool compounds for studying enzyme mechanisms and biological pathways.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Thiophenecarbonitrile, 5-Formyltetrahydro-, cis- (9Ci)
CAS No.	119292-49-8
Molecular Formula	C7H7NOS
Molecular Weight	153.20 g/mol
Synonyms	cis-5-Formyltetrahydro-2-thiophenecarbonitrile; (3aS,6aR)-Tetrahydro-5-formyl-2-thiophenecarbonitrile; 5-Formyl-2-thiophenecarbonitrile, tetrahydro-, cis-; Tetrahydro-5-formyl-2-thiophenecarbonitrile (cis-); cis-2-Cyano-5-formyltetrahydrothiophene; 2-Thiophenecarbonitrile, tetrahydro-5-formyl-, cis-; (cis)-Tetrahydro-5-formylthiophene-2-carbonitrile
EINECS	Contact for details

Quality Control

Our 2-Thiophenecarbonitrile, 5-Formyltetrahydro-, cis- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and advanced synthesis. We provide comprehensive analytical data, including chiral purity verification by HPLC. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.