Description

1-Azabicyclo[2.2.1]Heptane-4-Carboxylic Acid is a specialized bicyclic organic compound featuring a carboxylic acid functional group on a constrained nitrogen-containing bridgehead structure. This unique molecular architecture makes it a valuable and versatile building block in advanced organic synthesis and pharmaceutical research. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecules with specific stereochemical and pharmacological properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in neurological and cardiovascular drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its rigid structure can contribute to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: Its constrained bicyclic framework is utilized to design and synthesize peptide mimics for biomedical applications.
• Academic & Industrial R&D: A fundamental reagent in organic chemistry laboratories for methodological studies and the synthesis of complex natural product analogs.
• Fine Chemical Production: Employed in the custom synthesis of high-value, low-volume specialty chemicals for various technological applications.

Basic Information

Item	Details
Product Name	1-Azabicyclo[2.2.1]Heptane-4-Carboxylic Acid
CAS No.	119103-15-0
Molecular Formula	C7H11NO2
Molecular Weight	141.17 g/mol
Synonyms	1-Azanorbornane-4-carboxylic acid; 4-Carboxy-1-azabicyclo[2.2.1]heptane; endo-1-Azabicyclo[2.2.1]heptane-4-carboxylic acid; 1-Azabicyclo[2.2.1]heptane-4-carboxylic acid, endo-; Bicyclo[2.2.1]heptane-1-carboxylic acid, 4-aza-; (1R,4S)-1-Azabicyclo[2.2.1]heptane-4-carboxylic acid (for specific enantiomer); 4-Azabicyclo[2.2.1]heptane-1-carboxylic acid (alternative numbering)
EINECS	Contact for details

Quality Control

Every batch of 1-Azabicyclo[2.2.1]Heptane-4-Carboxylic Acid is manufactured under a strict quality management system. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with data from advanced techniques like HPLC, GC, NMR, and mass spectrometry to verify identity, purity, and chiral integrity. Our quality protocols are designed to meet the stringent requirements of cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (for enantiopure grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.