Description

(2S,4R)-3-Benzoyl-4-Methyl-2-Phenyl-5-Oxazolidinone CAS NO 118995-17-8 is a high-purity, chiral oxazolidinone derivative widely recognized as a versatile Evans auxiliary in asymmetric synthesis. This compound is critical for enabling highly stereoselective aldol and alkylation reactions, providing researchers and manufacturers with a reliable tool for constructing complex chiral molecules. It is an essential building block for pharmaceutical R&D, particularly in the synthesis of active pharmaceutical ingredients (APIs), fine chemicals, and advanced organic intermediates.

Application

• As a chiral auxiliary in Evans aldol reactions for the stereocontrolled formation of carbon-carbon bonds.
• Key starting material or intermediate in the asymmetric synthesis of pharmaceutical compounds, including β-lactam antibiotics and other chiral drugs.
• Use in academic and industrial research for developing novel synthetic methodologies and exploring new chemical space.
• Production of fine chemicals and specialty intermediates requiring high enantiomeric purity.
• Catalyst and ligand development for asymmetric catalysis.
• Building block for natural product synthesis and complex molecule construction.

Basic Information

Product Name	(2S,4R)-3-Benzoyl-4-Methyl-2-Phenyl-5-Oxazolidinone
CAS No.	118995-17-8
Molecular Formula	C18H15NO3
Molecular Weight	293.32 g/mol
Synonyms	(4R)-3-Benzoyl-4-Methyl-2-Phenyl-1,3-Oxazolidin-5-one; (2S,4R)-3-Benzoyl-4-Methyl-2-Phenyloxazolidin-5-one; Evans Auxiliary; (4R)-4-Methyl-3-benzoyl-2-phenyl-1,3-oxazolidin-5-one; (2S,4R)-4-Methyl-3-benzoyl-2-phenyl-1,3-oxazolidin-5-one; (4R)-4-Methyl-3-benzoyl-2-phenyl-5-oxazolidinone; (S,R)-3-Benzoyl-4-Methyl-2-Phenyl-5-Oxazolidinone
EINECS	Contact for details

Quality Control

Our (2S,4R)-3-Benzoyl-4-Methyl-2-Phenyl-5-Oxazolidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.