Description

(1S)-1-Phenyl-1,2,3,4-Tetrahydroisoquinoline is a chiral, non-racemic tetrahydroisoquinoline derivative, a privileged scaffold in medicinal chemistry. This compound matters as a versatile and high-value chiral building block for the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing new therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential central nervous system (CNS) agents, antitumor compounds, and other bioactive molecules.
• Asymmetric Synthesis: Employed as a chiral ligand or auxiliary in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs targeting various receptors.
• Agrochemical Development: Serves as a building block for creating novel chiral pesticides and herbicides with enhanced efficacy and selectivity.
• Fine Chemical Synthesis: Utilized in the production of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.

Basic Information

Product Name	(1S)-1-Phenyl-1,2,3,4-Tetrahydroisoquinoline
CAS No.	118864-75-8
Molecular Formula	C₁₅H₁₅N
Molecular Weight	209.29 g/mol
Synonyms	(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline; (1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline; (-)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline; (S)-1-Phenyl-1,2,3,4-THIQ; (S)-PTIQ; 1,2,3,4-Tetrahydro-1-phenylisoquinoline, (S)-; (S)-1-Phenyl-1,2,3,4-tetrahydro-isoquinoline
EINECS	Contact for details

Quality Control

Our (1S)-1-Phenyl-1,2,3,4-Tetrahydroisoquinoline is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity (enantiomeric excess) and chemical purity determination by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.