Description

Bengamide E is a potent, naturally occurring marine-derived metabolite belonging to the bengamide class of compounds, identified by CAS No. 118477-03-5. This compound is valued for its significant biological activity, particularly as a selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP2), a key target in anti-angiogenesis and cancer research. It serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate for researchers and developers in the pharmaceutical and biotechnology sectors, enabling the study of tumor biology and the development of novel therapeutics.

Application

• Pharmaceutical Research & Development: As a high-purity biochemical tool and reference standard for studying MetAP2 inhibition mechanisms and signaling pathways.
• Anticancer Agent Discovery: A key scaffold and intermediate in the synthesis and development of novel anti-angiogenic and antiproliferative drug candidates.
• Biochemical Assays: Used in in vitro and cell-based assays to validate targets and screen for synergistic compounds in oncology research.
• Academic Research: A vital compound for universities and research institutes investigating marine natural products, enzyme inhibition, and cancer cell biology.
• Preclinical Studies: Employed in animal model studies to evaluate pharmacokinetics, efficacy, and toxicity profiles of bengamide analogs.

Basic Information

Product Name	Bengamide E
CAS No.	118477-03-5
Molecular Formula	C₂₉H₄₉NO₇
Molecular Weight	523.71 g/mol
Synonyms	LAF 389; Bengamide E, LAF389; (2S,3R,4E,6E,8S,9S,10S,11S,12R)-11-[(2S)-2-[(2S,3S)-3-[(2S,3S)-3-Hydroxy-2-methylpentanoyl]oxy-2-methylpentanoyl]oxy-3-methylpentanoyl]oxy-2,9,10,12-tetramethyl-6-(2-methyl-1-propen-1-yl)-4,6,13-trioxabicyclo[9.3.1]pentadeca-1(14),11-dien-8-one; Bengamide E (LAF 389)
EINECS	Contact for details

Quality Control

Our Bengamide E is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities to ensure it meets the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.