Description

Bm-Cyclin CAS NO 118277-12-6 is a highly specific and potent inhibitor of cyclin-dependent kinases (CDKs), a class of enzymes critical for regulating the cell cycle. This compound is an essential research tool for studying cell proliferation, apoptosis, and signal transduction pathways in molecular biology and oncology research. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cancer therapeutics and cell biology.

Application

• Cell Cycle Research: A key reagent for investigating the mechanisms of cell division, checkpoint control, and the role of specific CDKs in various cell types.
• Oncology and Cancer Research: Used in in vitro and in vivo studies to inhibit tumor cell proliferation and to validate CDK targets for novel anti-cancer drug discovery.
• Biochemical Assay Development: Serves as a reference standard and active inhibitor in high-throughput screening (HTS) assays and enzymatic activity tests for CDK inhibitors.
• Signal Transduction Studies: Employed to dissect complex cellular signaling networks where CDK activity plays a regulatory role beyond the cell cycle.
• Apoptosis Research: Used to study the relationship between cell cycle arrest induced by CDK inhibition and the triggering of programmed cell death.
• Stem Cell Research: Applied in studies exploring the control of stem cell differentiation and self-renewal through cell cycle modulation.

Basic Information

Product Name	Bm-Cyclin
CAS No.	118277-12-6
Molecular Formula	C₁₉H₂₀N₆O₂
Molecular Weight	364.41 g/mol
Synonyms	Bm-Cyclin; BM-Cyclin; 2,6,9-Trisubstituted Purine Inhibitor; CDK Inhibitor Bm-Cyclin; (2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol; Purvalanol B; NG 95; NG-95
EINECS	Contact for details

Quality Control

Our Bm-Cyclin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR/LC-MS for structural confirmation, to ensure high batch-to-batch consistency and reliability for research applications. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.