Description

1,4-Dibenzyl-2,2,3,3-tetradeuteriopiperazine is a deuterium-labeled derivative of 1,4-dibenzylpiperazine, a valuable building block and intermediate in synthetic organic chemistry. This compound is specifically designed for applications requiring stable isotope labeling, such as in the development of internal standards for mass spectrometry and in mechanistic studies for drug metabolism and pharmacokinetics (DMPK). It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced analytical chemistry, medicinal chemistry, and the development of novel active pharmaceutical ingredients (APIs).

Application

• As a deuterated internal standard for the precise quantification of 1,4-dibenzylpiperazine and related compounds in biological matrices using LC-MS/MS.
• A key labeled synthetic intermediate in the research and development of deuterium-labeled pharmaceuticals for improved metabolic stability.
• Used in mechanistic studies and tracer experiments to elucidate metabolic pathways and reaction mechanisms.
• Employed in NMR spectroscopy as a tool for structural analysis and assignment due to the distinct properties of deuterium.
• Application in academic and industrial research focused on piperazine-based compounds, including ligands, catalysts, and polymers.

Basic Information

Product Name	1,4-Dibenzyl-2,2,3,3-tetradeuteriopiperazine
CAS No.	118221-01-5
Molecular Formula	C18H20D4N2
Molecular Weight	272.42 g/mol
Synonyms	1,4-Dibenzyl-2,2,3,3-d4-piperazine; 1,4-Dibenzylpiperazine-2,2,3,3-d4; 2,2,3,3-Tetradeuterio-1,4-dibenzylpiperazine; D4-1,4-Dibenzylpiperazine; N,N'-Dibenzylpiperazine-2,2,3,3-d4; 1,4-Bis(phenylmethyl)-2,2,3,3-tetradeuterio-piperazine; 1,4-Dibenzylpiperazine (2,2,3,3-d4)
EINECS	Contact for details

Quality Control

Our 1,4-Dibenzyl-2,2,3,3-tetradeuteriopiperazine is produced under strict quality management protocols to ensure high chemical purity and isotopic enrichment. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm structure, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing these specifications are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.