Description

6-(6-Amino-Hexyldisulfanyl)-Hexylamine Hydrochloride is a specialized bifunctional cross-linking agent featuring both a primary amine group and a cleavable disulfide bond. This compound is critical for creating reversible linkages in bioconjugation and materials science, offering precise control over molecular assembly and disassembly. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced polymer sectors for applications such as drug delivery system development, protein modification, and the synthesis of smart materials.

Application

• Bioconjugation and Protein Modification: Used to create reversible cross-links between biomolecules, enabling studies of protein interactions and the development of antibody-drug conjugates (ADCs).
• Drug Delivery Systems: Serves as a key linker in the design of stimuli-responsive nanocarriers, where the disulfide bond cleaves in the reductive intracellular environment for targeted drug release.
• Surface Functionalization: Employed to modify surfaces (e.g., gold nanoparticles, chips) with amine-reactive groups for biosensor and diagnostic assay development.
• Polymer Chemistry: Acts as a monomer or cross-linker in the synthesis of degradable polymers and hydrogels with redox-sensitive properties.
• Peptide Synthesis: Utilized as a building block or protecting group strategy in solid-phase peptide synthesis (SPPS) to introduce cleavable sites.
• Material Science Research: Applied in the development of novel smart materials that respond to biological reducing agents like glutathione.

Basic Information

Product Name	6-(6-Amino-Hexyldisulfanyl)-Hexylamine Hydrochloride
CAS No.	118077-46-6
Molecular Formula	C₁₂H₂₉ClN₂S₂
Molecular Weight	309.0 g/mol (approx.)
Synonyms	6,6'-Dithiobis(hexanamine) dihydrochloride; N,N'-(Dithiodi-1,6-hexanediyl)bisamine dihydrochloride; 1,6-Hexanediamine, N,N'-dithiodi-, dihydrochloride; Bis(6-aminohexyl) disulfide dihydrochloride; AHDA·2HCl; Cleavable amine-PEG crosslinker precursor; Disulfide-containing diamine hydrochloride
EINECS	Contact for details

Quality Control

Our 6-(6-Amino-Hexyldisulfanyl)-Hexylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and titration for assay determination, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.