Description

Di-tert-Butyl N,n-Diethylphosphoramidite is a high-purity organophosphorus reagent widely used as a key intermediate in chemical synthesis. This compound is valued for its role as a versatile phosphitylating agent, enabling the efficient construction of complex molecular architectures. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as oligonucleotide synthesis and catalyst development.

Application

• Phosphoramidite Intermediate: A critical building block in the solid-phase synthesis of oligonucleotides (DNA/RNA) for therapeutic and diagnostic applications.
• Ligand Precursor: Used in the preparation of specialized phosphine ligands for homogeneous catalysis and cross-coupling reactions.
• Chemical Research: Serves as a versatile reagent in organic synthesis for introducing phosphorus-containing functional groups.
• Agrochemical Synthesis: Employed as an intermediate in the development of novel pesticides and herbicides.
• Material Science: Utilized in the synthesis of phosphorus-based polymers and flame retardants.
• Process Development: Applied in scale-up and optimization of synthetic routes in fine chemical manufacturing.

Basic Information

Product Name	Di-tert-Butyl N,n-Diethylphosphoramidite
CAS No.	117924-33-1
Molecular Formula	C12H28NO2P
Molecular Weight	249.33 g/mol
Synonyms	Di-tert-butyl N,N-diethylphosphoramidite; N,N-Diethyl-P,P-di-tert-butylphosphoramidite; Di-tert-butyl(diethylamino)phosphine; Phosphoramidous acid, N,N-diethyl-, bis(1,1-dimethylethyl) ester; (Di-tert-butoxy)(diethylamino)phosphine; DTBDEP; t-Bu2PNEt2
EINECS	Contact for details

Quality Control

Our Di-tert-Butyl N,n-Diethylphosphoramidite is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and HPLC, to ensure high purity and consistency. Certificates of Analysis (COA) detailing specific batch results are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.