Description

1,3,7-Trimethyluric Acid-D9 is a high-purity, deuterium-labeled internal standard critical for quantitative analytical applications. This compound is essential for ensuring accuracy and precision in mass spectrometry-based methods, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities requiring reliable isotopic standards for method validation and regulatory compliance.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of caffeine and its primary metabolites in biological matrices.
• Pharmaceutical Research: Facilitates drug metabolism and pharmacokinetics (DMPK) studies for compounds related to the xanthine family.
• Clinical Toxicology: Enables accurate measurement of methylxanthine levels in plasma and urine for therapeutic drug monitoring and overdose cases.
• Nutraceutical & Sports Science Analysis: Supports the analysis of caffeine content and its metabolic fate in dietary supplements and performance studies.
• Method Development & Validation: Serves as a critical reference material for developing and validating robust bioanalytical assays in compliance with GLP guidelines.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy measurement techniques where minimal isotopic interference is paramount.

Basic Information

Item	Detail
Product Name	1,3,7-Trimethyluric Acid-D9
CAS No.	117490-42-3
Molecular Formula	C8D9H2N4O3
Molecular Weight	207.23 g/mol (deuterated form)
Synonyms	1,3,7-Trimethyluric Acid-d9; [2,4,6,8-2H9]-1,3,7-Trimethyluric Acid; Caffeine Metabolite-d9 (1,3,7-TMU-d9); Uric Acid, 1,3,7-trimethyl-, d9; 1,3,7-Tri-O-methyluric Acid-D9; Deuterated 1,3,7-Trimethyluric Acid; TMU-d9; Internal Standard for Caffeine Metabolism
EINECS	Contact for details

Quality Control

Every batch of 1,3,7-Trimethyluric Acid-D9 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical reference standards. Comprehensive testing includes assay, isotopic enrichment (D9), and identification by spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to ensure full traceability and compliance with your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D9)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.