Description

Dimethyl ((3Ar,4R,6R,6Ar)-6-(Benzyloxymethyl)-4-Hydroxy-2,2-Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)Methylphosphonate is a sophisticated chiral phosphonate derivative, a key synthetic intermediate in advanced organic chemistry. This compound is valued for its role in constructing complex molecular architectures, particularly in the synthesis of nucleoside analogs and other biologically active molecules. It is essential for research and development in the pharmaceutical and agrochemical industries, where precise stereochemistry and functional group manipulation are critical.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Agrochemical Research: Used in the development of new pesticides and herbicides with specific chiral activity.
• Chemical Synthesis: Serves as a versatile precursor for the introduction of phosphonate groups in complex organic molecules.
• Academic & R&D: A valuable reagent for methodological studies in asymmetric synthesis and carbohydrate chemistry.
• Bioconjugate Chemistry: Potential use in creating phosphonate-linked probes and drug conjugates.

Basic Information

Product Name	Dimethyl ((3Ar,4R,6R,6Ar)-6-(Benzyloxymethyl)-4-Hydroxy-2,2-Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)Methylphosphonate
CAS No.	117251-95-3
Molecular Formula	C19H27O8P
Molecular Weight	414.39 g/mol
Synonyms	Dimethyl (4R,6R)-6-(Benzyloxymethyl)-4-hydroxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ylmethylphosphonate; (4R,6R)-6-(Benzyloxymethyl)-4-hydroxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ylmethylphosphonic Acid Dimethyl Ester; Phosphonate Derivative of Isopropylidene Protected D-Glucose; CAS 117251-95-3
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and chiral analysis. A Certificate of Analysis (COA) detailing purity, identity, and chiral purity is provided with each shipment to support your R&D and cGMP-compliant workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.