Description

1-(3-Mercapto-1-Oxopropoxy)-2,5-Pyrrolidinedione is a specialized chemical intermediate featuring a unique combination of a maleimide and a thioester functional group. This compound matters for its role as a versatile building block in advanced organic synthesis, particularly for creating functionalized polymers and bioconjugates. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, polymer science, and materials research sectors for developing targeted drug delivery systems, cross-linked hydrogels, and surface-modified materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics via thiol-maleimide click chemistry.
• Polymer Modification: Used to introduce thiol-reactive sites into polymer backbones for creating cross-linked networks, hydrogels, and smart materials.
• Bioconjugation: Facilitates the site-specific labeling of peptides, proteins, and antibodies with various payloads such as fluorophores, drugs, or polymers.
• Surface Functionalization: Enables the covalent attachment of bioactive molecules to surfaces for biosensor development and diagnostic assay platforms.
• Research & Development: Serves as a critical reagent in academic and industrial R&D for exploring new synthetic pathways in medicinal and polymer chemistry.
• Material Science: Employed in the development of advanced functional materials with tailored mechanical and chemical properties.

Basic Information

Product Name	1-(3-Mercapto-1-Oxopropoxy)-2,5-Pyrrolidinedione
CAS No.	117235-10-6
Molecular Formula	C7H7NO4S
Molecular Weight	201.20 g/mol
Synonyms	3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanethioic S-acid; 1-(3-Mercaptocarbonylpropionyloxy)pyrrole-2,5-dione; 3-Maleimidopropanethioic Acid; Maleimidopropanethioate; N-(3-Carboxypropionyl)maleimide thioester; Thioester-linked maleimide; SMPT analogue; Bioconjugation linker 117235-10-6
EINECS	Contact for details

Quality Control

Our 1-(3-Mercapto-1-Oxopropoxy)-2,5-Pyrrolidinedione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) documenting full specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated place, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.