Description

Nicotinic Acid-D1 is a deuterium-labeled isotopologue of nicotinic acid (vitamin B3), specifically designed for use as an internal standard in advanced analytical techniques. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analyses in research and quality control laboratories. It is primarily utilized by scientists and manufacturers in the pharmaceutical, nutraceutical, and analytical chemistry sectors for applications requiring precise measurement and metabolic pathway tracing.

Application

• Internal Standard for LC-MS/MS and GC-MS: Critical for the accurate quantification of nicotinic acid and its metabolites in complex biological matrices like plasma, serum, and tissue samples.
• Pharmacokinetic and Metabolic Studies: Enables precise tracking of drug metabolism and nutrient absorption in preclinical and clinical research.
• Stable Isotope Dilution Assays: Used in high-accuracy methods for determining vitamin B3 content in fortified foods, dietary supplements, and pharmaceutical formulations.
• Biochemical Research: Serves as a tracer to study enzymatic pathways involving nicotinic acid, including NAD biosynthesis.
• Quality Control & Method Development: Supports the development and validation of robust analytical methods in pharmaceutical and contract research organizations (CROs).

Basic Information

Product Name	Nicotinic Acid-D1
CAS No.	116975-14-5
Molecular Formula	C6H4DNO2
Molecular Weight	124.12 g/mol
Synonyms	Pyridine-3-carboxylic-2,4,5,6-d4 acid; Deuterated Nicotinic Acid; Vitamin B3-d1; 3-Carboxypyridine-d1; Niacin-d1; 3-Pyridinecarboxylic acid-d1; Nicotinic acid (deuterated); Pyridine-3-carboxylic acid (deuterated)
EINECS	Contact for details

Quality Control

Our Nicotinic Acid-D1 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity. Each batch is analyzed using state-of-the-art techniques including NMR and Mass Spectrometry to confirm deuteration level and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (e.g., D-atom %), chemical purity, and analytical results is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0% (by NMR or MS)
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.