Description

(S)-n-Methyl-3-(Naphthalen-1-Yloxy)-3-(Thiophen-3-Yl)Propan-1-Amine CAS NO 116817-27-7 is a high-purity chiral amine intermediate of significant importance in advanced organic synthesis. Its value lies in its unique molecular architecture, which incorporates both naphthalene and thiophene moieties, making it a versatile building block for creating complex, functional molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel central nervous system (CNS) agents, receptor modulators, and other bioactive molecules.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides that require specific stereochemistry for optimal activity.
• Ligand Synthesis: Serves as a precursor for chiral ligands used in asymmetric catalysis, enhancing the efficiency and selectivity of chemical transformations.
• Material Science: Potential monomer or additive for creating specialty polymers with tailored electronic or optical properties, leveraging the thiophene unit.
• Academic & Contract Research: A critical reagent for methodological studies in organic chemistry, particularly in stereoselective synthesis and heterocyclic chemistry.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fine chemicals and custom-synthesized compounds for various industrial applications.

Basic Information

Product Name	(S)-n-Methyl-3-(Naphthalen-1-Yloxy)-3-(Thiophen-3-Yl)Propan-1-Amine
CAS No.	116817-27-7
Molecular Formula	C₁₈H₁₉NOS
Molecular Weight	297.41 g/mol
Synonyms	(S)-N-Methyl-3-(1-naphthyloxy)-3-(3-thienyl)propylamine; (S)-1-(Methylamino)-3-(naphthalen-1-yloxy)-3-(thiophen-3-yl)propane; (S)-N-Methyl-3-(1-naphthalenyloxy)-3-(3-thienyl)-1-propanamine; (S)-3-(1-Naphthyloxy)-3-(3-thienyl)-N-methylpropylamine; (S)-N-Methyl-3-(1-naphthoxy)-3-(3-thienyl)propylamine; (S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-3-yl)propan-1-amine; 116817-27-7; (S)-enantiomer of the NMTPA derivative.
EINECS	Contact for details

Quality Control

Our production of (S)-n-Methyl-3-(Naphthalen-1-Yloxy)-3-(Thiophen-3-Yl)Propan-1-Amine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) to confirm identity, chiral purity (>99% ee typical), and chemical assay. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.