Description

(Rs)-n-Methyl-Gama-(1-Naphthalenyloxy)-2-Thiophenepropanamine Hydrochloride is a high-purity chiral chemical intermediate of significant interest in advanced pharmaceutical synthesis. This compound matters for its role as a key building block in the development of active pharmaceutical ingredients (APIs), particularly those targeting neurological pathways. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, process chemistry, and analytical method development.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the synthesis of complex drug candidates, particularly in central nervous system (CNS) research.
• Biochemical Research: Used as a reference standard or reagent in pharmacological studies investigating receptor binding and activity.
• Process Development: Employed in route scouting and optimization for the scalable production of target APIs.
• Analytical Standard: Utilized for method development and validation in quality control laboratories to ensure product purity and identity.
• Asymmetric Synthesis: Acts as a chiral auxiliary or building block in stereoselective chemical transformations.

Basic Information

Product Name	(Rs)-n-Methyl-Gama-(1-Naphthalenyloxy)-2-Thiophenepropanamine Hydrochloride
CAS No.	116817-11-9
Molecular Formula	C₁₈H₂₀ClNOS
Molecular Weight	333.87 g/mol
Synonyms	(R,S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride; Duloxetine Impurity; (RS)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride; LY248686 Hydrochloride; Thiophene propanamine derivative; N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride; Duloxetine Related Compound
EINECS	Contact for details

Quality Control

Our (Rs)-n-Methyl-Gama-(1-Naphthalenyloxy)-2-Thiophenepropanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods, to ensure it meets stringent specifications for research and development use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.