Description

2,2,2-Trifluoro-1-(1-Methyl-1H-Indol-3-Yl)-1-Ethanol is a high-value fluorinated indole derivative, a key chiral building block in advanced organic synthesis. Its core value lies in the trifluoroethanol moiety, which introduces unique electronic and steric properties critical for modulating the biological activity and metabolic stability of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the development of new drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance lipophilicity and biological activity.
• Material Science Precursor: Serves as a building block for specialty polymers and advanced organic materials with specific optical or electronic properties.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the study of novel catalytic reactions due to its defined stereochemistry.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research focused on the synthesis and reactivity of organofluorine molecules.

Basic Information

Product Name	2,2,2-Trifluoro-1-(1-Methyl-1H-Indol-3-Yl)-1-Ethanol
CAS No.	116757-91-6
Molecular Formula	C11H10F3NO
Molecular Weight	229.20 g/mol
Synonyms	α-(Trifluoromethyl)-1-methyl-1H-indole-3-methanol; 1-(1-Methyl-1H-indol-3-yl)-2,2,2-trifluoroethanol; 3-(2,2,2-Trifluoro-1-hydroxyethyl)-1-methyl-1H-indole; 2,2,2-Trifluoro-1-(1-methylindol-3-yl)ethanol; 1-Methyl-3-(2,2,2-trifluoro-1-hydroxyethyl)indole; TFMIE; (RS)-2,2,2-Trifluoro-1-(1-methyl-1H-indol-3-yl)ethanol
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(1-Methyl-1H-Indol-3-Yl)-1-Ethanol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.