Description

2,2,2-Trifluoro-1-(1H-Indol-3-Yl)-Ethanol is a high-value fluorinated indole derivative, a crucial chiral building block in advanced organic synthesis. Its unique structure, featuring both a trifluoroethanol moiety and an indole ring, makes it an indispensable intermediate for creating novel compounds with enhanced biological activity and metabolic stability. This compound is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for the development of new active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated pesticides and herbicides where the trifluoromethyl group improves lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and organic electronic materials due to the electron-withdrawing properties of the CF3 group.
• Fluorine Chemistry Studies: An important compound for academic and industrial research exploring the effects of fluorine substitution on molecular properties.

Basic Information

Product Name	2,2,2-Trifluoro-1-(1H-Indol-3-Yl)-Ethanol
CAS No.	116757-85-8
Molecular Formula	C10H8F3NO
Molecular Weight	215.17 g/mol
Synonyms	3-(2,2,2-Trifluoro-1-hydroxyethyl)-1H-indole; 1H-Indole-3-ethanol, 2,2,2-trifluoro-; 2,2,2-Trifluoro-1-(3-indolyl)ethanol; α-(Trifluoromethyl)-1H-indole-3-ethanol; (RS)-2,2,2-Trifluoro-1-(1H-indol-3-yl)ethanol; Trifluoroindole Ethanol; TFIE; CAS 116757-85-8
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(1H-Indol-3-Yl)-Ethanol is manufactured under strict quality management systems. We offer material suitable for research and development purposes, with typical purity levels exceeding 95% (by HPLC). Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. For cGMP, USP, or other specific pharmacopeial grade requirements, please contact our technical sales team to discuss custom synthesis and qualification protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.