Description

3-Thiophenecarboxylic Acid, 4-(Chlorocarbonyl)-, Methyl Ester (9Ci) is a high-purity, multifunctional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the presence of both a reactive acid chloride moiety and a methyl ester group on a thiophene scaffold, enabling precise and sequential derivatization. This compound is essential for research chemists and process development scientists working in pharmaceutical discovery and material science. It serves as a key precursor for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and functional organic materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially those containing thiophene-based heterocycles which are prevalent in various therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the thiophene ring can contribute to biological activity.
• Material Science Precursor: Employed in the creation of organic semiconductors, conductive polymers, and non-linear optical (NLO) materials due to the electron-rich nature of the thiophene unit.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on heterocyclic chemistry, medicinal chemistry, and polymer science.
• Fine Chemical Production: Utilized in the multi-step synthesis of complex, high-value specialty chemicals and dyes.

Basic Information

Product Name	3-Thiophenecarboxylic Acid, 4-(Chlorocarbonyl)-, Methyl Ester (9Ci)
CAS No.	116722-20-4
Molecular Formula	C7H5ClO3S
Molecular Weight	204.63 g/mol
Synonyms	4-(Chlorocarbonyl)-3-thiophenecarboxylic acid methyl ester; Methyl 4-(chlorocarbonyl)thiophene-3-carboxylate; 3-Thiophenecarboxylic acid, 4-(chlorocarbonyl)-, methyl ester; Methyl 4-chloroformylthiophene-3-carboxylate; Thiophene-3,4-dicarboxylic acid 4-chloride 3-methyl ester; 4-Carboxy-3-thiophenecarboxylic acid methyl ester chloride; 3-(Methoxycarbonyl)thiophene-4-carbonyl chloride
EINECS	Contact for details

Quality Control

Our 3-Thiophenecarboxylic Acid, 4-(Chlorocarbonyl)-, Methyl Ester (9Ci) is produced under strict quality management protocols. We offer material suitable for research and development purposes, with typical purity levels exceeding 95% (by HPLC). Each batch is characterized by modern analytical techniques to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specific batch results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis of the acid chloride functionality. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.